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Article

Complex Roles of Inflammasomes in Carcinogenesis

1 Nov 2013

Abstract excerpt

The central role of chronic inflammation in the promotion of tumor growth is supported by a broad range of experimental and clinical evidence. However, the molecular mechanisms converting transient inflammatory tissue reactions into a tumor-promoting microenvironment remain largely elusive. Because inflammasomes have been shown to regulate the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18, they have...

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PMID: 24270345
DOI: 10.1097/ppo.0000000000000004

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