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Article

Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2012

Rogue Alexandra, Lambert Carine, Spire Catherine, Claude Nancy, Guillouzo André

Abstract excerpt

Interindividual variations in functions other than drug metabolism activity, remain poorly elucidated in human liver. In the present study, the whole transcriptome of several human hepatocyte populations and the differentiated human HepaRG cell line have been analyzed and compared, using oligonucleotide pangenomic microarrays. We show that, although the variation in the percentages of expressed genes did not...

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Identifiers

PMID: 21994436
DOI: 10.1124/dmd.111.042028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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