Article
The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment.
Experimental hematology - 1 Mar 2014
Iwamoto Chika, Takenaka Katsuto, Urata Shingo, Yamauchi Takuji, Shima Takahiro, Kuriyama Takuro, Daitoku Shinya, Saito Yasuyuki, Miyamoto Toshihiro, Iwasaki Hiromi, Kitabayashi Issay, Itoh Katsuhiko, Kishimoto Junji, Kohda Daisuke, Matozaki Takashi, Akashi Koichi
Abstract excerpt
It has been shown that in xenotransplantation of human cells into immunodeficient mice, the mouse strain background is critical. For example, the nonobese diabetic (NOD) strain is most efficient, the BALB/c is moderate, and the C57BL/6 is inefficient for human cell engraftment. We have shown that the NOD-specific polymorphism of the signal regulatory protein-alpha (Sirpa) allows NOD SIRPA to bind human CD47, and...
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