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Article

Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47.

Journal of molecular biology - 19 Jan 2007

Liu Yuan, Tong Qiao, Zhou Yubin, Lee Hsiau-Wei, Yang Jenny J, Bühring Hans-Jörg, Chen Yi-Tien, Ha Binh, Chen Celia X-J, Yang Yang, Zen Ke

Abstract excerpt

SIRPalpha and SIRPbeta1, the two major isoforms of the signal regulatory protein (SIRP) family, are co-expressed in human leukocytes but mediate distinct extracellular binding interactions and divergent cell signaling responses. Previous studies have demonstrated that binding of SIRPalpha with CD47, another important cell surface molecule, through the extracellular IgV domain regulates important leukocyte...

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Identifiers

PMID: 17070842
DOI: 10.1016/j.jmb.2006.09.079
PMCID: PMC1855148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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