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Article

Role for CD47-SIRPα signaling in xenograft rejection by macrophages

13 Mar 2007

Abstract excerpt

We have previously proven that human macrophages can phagocytose porcine cells even in the absence of Ab or complement opsonization, indicating that macrophages present a pivotal immunological obstacle to xenotransplantation. A recent report indicates that the signal regulatory protein (SIRP)alpha is a critical immune inhibitory receptor on macrophages, and its interaction with CD47, a ligand for SIRPalpha,...

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Identifiers

PMID: 17360380
DOI: 10.1073/pnas.0609661104

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