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Article

Polymorphisms in the human inhibitory signal-regulatory protein α do not affect binding to its ligand CD47.

The Journal of biological chemistry - 4 Apr 2014

Hatherley Deborah, Lea Susan M, Johnson Steven, Barclay A Neil

Abstract excerpt

CD47 is a widely distributed membrane protein that interacts with signal-regulatory protein α (SIRPα), an inhibitory receptor on myeloid cells that gives a "don't-eat-me" signal. Manipulation of the interaction is of considerable interest in the immunotherapy of cancer and in xenotransplantation....

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Identifiers

PMID: 24550402
DOI: 10.1074/jbc.M114.550558
PMCID: PMC3974974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24550402-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Polymorphisms in the human inhibitory signal-regulatory protein α do not affect binding to its ligand CD47.PMID 24550402Read ↗

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