Signal‐regulatory protein <i>α</i> from the <scp>NOD</scp> mouse binds human <scp>CD</scp>47 with an exceptionally high affinity – implications for engraftment of human cells

Abstract excerpt

One common way to study human leucocytes and cancer cells in an experimental in vivo situation is to use mice that have been genetically engineered to lack an immune system and prevent human cell rejection. These mice lack CD132 and either RAG2 or the catalytic subunit of the DNA-dependent protein kinase, to make the mice deficient in lymphocytes and natural killer cells. The NOD mouse strain provides a better...

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