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Article

Activation of the Influenza B M2 Proton Channel (BM2).

Biochemistry - 19 Nov 2024

Yue Zhi, Wu Jiangbo, Teng Da, Wang Zhi, Voth Gregory A

Abstract excerpt

Influenza B viruses have cocirculated during most seasonal flu epidemics and can cause significant human morbidity and mortality due to their rapid mutation, emerging drug resistance, and severe impact on vulnerable populations. The influenza B M2 proton channel (BM2) plays an essential role in viral replication, but the mechanisms behind its symmetric proton conductance and the involvement of a second histidine...

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Identifiers

PMID: 39488842
DOI: 10.1021/acs.biochem.4c00607
PMCID: PMC11580745

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