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Article

Studies of structural changes in the M2 proton channel of influenza A virus by tryptophan fluorescence.

Virus research - 1 Jan 2004

Czabotar Peter E, Martin Stephen R, Hay Alan J

Abstract excerpt

Studies of tryptophan fluorescence of purified influenza A virus M2 protein have identified two pH-dependent structural changes. (1) An increase in fluorescence on reduction of pH from 8 to 6 that involves tryptophan 15 within the N-terminal domain of the protein and may be associated with proton activation of the channel. (2) Quenching of the fluorescence of tryptophan 41 within the transmembrane domain of the...

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Identifiers

PMID: 14687947
DOI: 10.1016/j.virusres.2003.10.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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