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Article

Agnogene deletion in a novel pathogenic JC virus isolate impairs VP1 expression and virion production.

PloS one - 1 Jan 2013

Ellis Laura C, Norton Elizabeth, Dang Xin, Koralnik Igor J

Abstract excerpt

Infection of glial cells by the human polyomavirus JC (JCV) causes progressive multifocal leukoencephalopathy (PML). JCV Encephalopathy (JCVE) is a newly identified disease characterized by JCV infection of cortical pyramidal neurons. The virus JCVCPN associated with JCVE contains a unique 143 base pair deletion in the agnogene. Contrary to most JCV brain isolates, JCVCPN has an archetype-like regulatory region...

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Identifiers

PMID: 24265839
DOI: 10.1371/journal.pone.0080840
PMCID: PMC3827225

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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