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Article

Genetic Diversity of the Polyomavirus JC and Implications for the Pathogenesis of Progressive Multifocal Leukoencephalopathy.

Viruses - 18 Mar 2026

Wilczek Michael P, Lhomme Sebastien

Abstract excerpt

JC Polyomavirus (JCPyV) is a non-enveloped virus with circular double stranded DNA responsible for the rare but fatal demyelinating disease known as progressive multifocal leukoencephalopathy (PML). In its host, this virus exists in two different forms: one found in the periphery, named archetype, and another found in the central nervous system, named prototype. This form usually harbors recombinations in the...

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Identifiers

PMID: 41902286
DOI: 10.3390/v18030378
PMCID: PMC13030862

Genes

PML

Provenance

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