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Clinical implications of tumor-based next-generation sequencing in high-grade epithelial ovarian cancer.

Cancer - 1 Jun 2023

Foster Katherine I, Shaw Kenna R M, Jin Jeff, Westin Shannon N, Yap Timothy A, Glassman Deanna M, Jazaeri Amir A, Rauh-Hain Jose A, Lee Sanghoon, Fellman Bryan M, Ju Zhenlin, Liu Yuexin, Fleming Nicole D, Sood Anil K

Abstract excerpt

BACKGROUND: Tumor-based next-generation sequencing is used inconsistently as a tool to tailor treatment of ovarian cancer, yet beyond detection of somatic BRCA1 and BRCA2 mutations, the clinical benefit is not well established. This study aimed to assess the clinical relevance of tumor-based next-generation sequencing (tbNGS) in patients with ovarian cancer. METHODS: This retrospective study included patients...

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Carcinoma, Ovarian Epithelial
High-Throughput Nucleotide Sequencing
Mutation
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36930815
DOI: 10.1002/cncr.34724

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