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Article

Burden of unique and low prevalence somatic mutations correlates with cancer survival

19 Mar 2019

Abstract excerpt

Tumor mutational burden correlates with improved survival and immunotherapy response in some malignancies, and with tumor aggressiveness in others. To study the link between mutational burden and survival, we analyzed survival effects of tumor exonic missense mutation burden (TEMMB) across 6947 specimens spanning 31 cancers which have undergone whole exome sequencing as part of TCGA. We adjusted TEMMB for age,...

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PMID: 30890735
DOI: 10.1038/s41598-019-41015-5

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