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Article

Quick, sensitive and specific detection and evaluation of quantification of minor variants by high-throughput sequencing.

Molecular bioSystems - 1 Feb 2014

Leung Ross Ka-Kit, Dong Zhi Qiang, Sa Fei, Chong Cheong Meng, Lei Si Wan, Tsui Stephen Kwok-Wing, Lee Simon Ming-Yuen

Abstract excerpt

Minor variants have significant implications in quasispecies evolution, early cancer detection and non-invasive fetal genotyping but their accurate detection by next-generation sequencing (NGS) is hampered by sequencing errors. We generated sequencing data from mixtures at predetermined ratios in order to provide insight into sequencing errors and variations that can arise for which simulation cannot be...

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PMID: 24264059
DOI: 10.1039/c3mb70334g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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