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Article

Performance Evaluation of Whole-Genome Amplification Platforms for Clinical Next-Generation Sequencing with Minimal Nucleic Acid Input.

Annals of laboratory medicine - 1 Jul 2026

Kim Namsoo, Lee Hyeon Ah, Park Miri, Kang Yehyun, Won Dongju, Lee Seung-Tae, Choi Jong Rak, Park Yu Jin, Shin Saeam

Abstract excerpt

Background: Next-generation sequencing (NGS) is increasingly applied in clinical diagnostics; however, standard workflows are frequently challenged by insufficient DNA yields in diverse clinical scenarios. Although whole-genome amplification (WGA) is used to overcome this limitation, comparative performance data on WGA kits based on different amplification mechanisms under low-input conditions remain scarce....

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PMID: 41277018
DOI: 10.3343/alm.2025.0348
PMCID: PMC13259937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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