Article
Azobenzene switch with a long-lived cis-state to photocontrol the enzyme activity of a histone deacetylase-like amidohydrolase.
Biological chemistry - 1 Apr 2014
Korbus Michael, Balasubramanian Ganesh, Müller-Plathe Florian, Kolmar Harald, Meyer-Almes Franz-Josef
Abstract excerpt
The control of enzymes by use of an external stimulus such as light enables the temporal and spatial regulation of defined chemical reactions in a highly precise manner. In this work we investigated and characterized the reversible photocontrol of a bacterial histone deacetylase-like amidohydrolase (HDAH) from Bordetella/Alcaligenes strain FB188, which holds great potential to control deacetylation reactions of a...
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