Article

Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within Interleukin-6 family cytokines

2024-04-26

Abstract excerpt

Although aberrant activation of the KRAS and PI3K pathway alongside TP53 mutations account for frequent aberrations in human gastric cancers, neither the sequence nor the individual contributions of these mutations have been clarified. Here, we establish an allelic series of mice to afford conditional expression in glandular epithelium of Kras G12D ; Pik3ca H1047R or Trp53 R172H and/or ablation of Pten or...

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Literature Corpus work: c0e5f1db-4413-5aa6-9c5b-6e7469bc623c
DOI: 10.1101/2024.04.22.590499

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