Article
Slug/β-catenin-dependent proinflammatory phenotype in hypoxic breast cancer stem cells.
The American journal of pathology - 1 Nov 2013
Storci Gianluca, Bertoni Sara, De Carolis Sabrina, Papi Alessio, Nati Marina, Ceccarelli Claudio, Pirazzini Chiara, Garagnani Paolo, Ferrarini Alberto, Buson Genny, Delledonne Massimo, Fiorentino Michelangelo, Capizzi Elisa, Gruppioni Elisa, Taffurelli Mario, Santini Donatella, Franceschi Claudio, Bandini Giuseppe, Bonifazi Francesca, Bonafé Massimiliano
Abstract excerpt
Cancer stem cell survival relies on the activation of inflammatory pathways, which is speculatively triggered by cell autonomous mechanisms or by microenvironmental stimuli. Here, we observed that hypoxic bone marrow stroma-derived transforming growth factor-β 1 promotes the growth of human breast cancer stem cells as mammospheres. The ensuing Slug-dependent serine 139 phosphorylation of the DNA damage sensor...
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