Article
Tamoxifen selects for breast cancer cells with mammosphere forming capacity and increased growth rate.
Breast cancer research and treatment - 1 Dec 2013
Raffo Diego, Berardi Damian E, Pontiggia Osvaldo, Todaro Laura, de Kier Joffé Elisa Bal, Simian Marina
Abstract excerpt
Using the M05 mouse mammary tumor model and the MCF-7 cell line, we investigated the effect of tamoxifen treatment on the fraction of breast cancer cells with self-renewing capacity both in vitro and in vivo. We found that pretreatment with 4-OH-tamoxifen leads to an increase in cells with the ab...
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