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Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?

25 May 2011

Abstract excerpt

In vivo transplantation is the current 'gold-standard' assay for evaluating mammary stem cell (MaSC) function. Matrigel, a reconstituted extracellular matrix derived from a mouse sarcoma line, is increasingly being utilized for mammary repopulating assays, although original studies were carried out in its absence. This matrix has also been shown to enhance tumor-initiating capacity. Whilst Matrigel increases the...

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PMID: 21635708
DOI: 10.1186/bcr2851

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