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Phenotypic and Functional Characterization of Human Mammary Stem/Progenitor Cells in Long Term Culture

23 Apr 2009

Abstract excerpt

BACKGROUND: Cancer stem cells exhibit close resemblance to normal stem cells in phenotype as well as function. Hence, studying normal stem cell behavior is important in understanding cancer pathogenesis. It has recently been shown that human breast stem cells can be enriched in suspension cultures as mammospheres. However, little is known about the behavior of these cells in long-term cultures. Since extensive...

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PMID: 19390630
DOI: 10.1371/journal.pone.0005329

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