Article
A novel approach applying a chemical biology strategy in phenotypic screening reveals pathway-selective regulators of histone 3 K27 tri-methylation.
Molecular bioSystems - 1 Feb 2014
Liu Yan, Platchek Michael, Kement Burcu, Bee Weilin T, Truong Maggie, Zeng Xin, Hung Sunny, Lin Hong, Morrow Dwight, Kallal Lorena A, Xie Qing, Agarwal Pankaj, Pope Andrew J, Wu Zining
Abstract excerpt
Epigenetic regulation by histone methylation is crucial for proper programming of the genome during development. Homeostasis of histone methylation is balanced by the activities of histone methyltransferases and demethylases. Although these methyltransferases and demethylases represent logical ta...
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