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Article

Tumour suppressor gene function in carcinoma‐associated fibroblasts: from tumour cells via EMT and back again?

19 Nov 2013

Abstract excerpt

Recent reports indicate that inactivation of the RB, TP53 or PTEN tumour suppressor genes is detected in tumour stroma of oropharyngeal, breast and other human cancers. Mouse models have validated the tumour-promoting effects of deleting Rb, Pten or p53 in fibroblasts that converts them from normal fibroblasts to carcinoma associated fibroblasts (CAFs). The tumour-promoting activity of CAFs in these contexts was...

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PMID: 24254977
DOI: 10.1002/path.4298

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