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Article

A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.

Carcinogenesis - 28 May 2018

Melling Genevieve E, Flannery Sarah E, Abidin Siti A, Clemmens Hannah, Prajapati Priyanka, Hinsley Emma E, Hunt Stuart, Catto James W F, Coletta Ricardo Della, Mellone Massimiliano, Thomas Gareth J, Parkinson E Ken, Prime Stephen S, Paterson Ian C, Buttle David J, Lambert Daniel W

Abstract excerpt

The dissemination of cancer cells to local and distant sites depends on a complex and poorly understood interplay between malignant cells and the cellular and non-cellular components surrounding them, collectively termed the tumour microenvironment. One of the most abundant cell types of the tumour microenvironment is the fibroblast, which becomes corrupted by locally derived cues such as TGF-β1 and acquires an...

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PMID: 29506142
DOI: 10.1093/carcin/bgy032

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