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Article

Effects of activated fibroblasts on phenotype modulation, EGFR signalling and cell cycle regulation in OSCC cells.

Experimental cell research - 1 Apr 2014

Berndt Alexander, Büttner Robert, Gühne Stefanie, Gleinig Anna, Richter Petra, Chen Yuan, Franz Marcus, Liebmann Claus

Abstract excerpt

Crosstalk between carcinoma associated fibroblasts (CAFs) and oral squamous cell carcinoma (OSCC) cells is suggested to mediate phenotype transition of cancer cells as a prerequisite for tumour progression, to predict patients' outcome, and to influence the efficacy of EGFR inhibitor therapies. Here we investigate the influence of activated fibroblasts as a model for CAFs on phenotype and EGFR signalling in OSCC...

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Source

Identifiers

PMID: 24394543
DOI: 10.1016/j.yexcr.2013.12.024

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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