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Article

[Association between parental MTHFR gene polymorphism 677C/T and nonsyndromic cleft lip and palate in offspring].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Aug 2012

Wang Su-mei, Wang Jian-hua, Yu Jian-chun, Wei Bin, Wang Ke-hua, Liu Jin-yun, Dong Yun-ling, Lv Xue-mei

Abstract excerpt

OBJECTIVE: To explore the association between parental genetic polymorphism of methylenetetrahydrofolate reductase (MTHFR) 677C/T and occurrence of nonsyndromic cleft lip with or without cleft palate (NSCL/P) in offspring in Shandong Province. METHODS: MTHFR genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Parents of 89 NSCL/P patients treated at Qilu...

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Identifiers

PMID: 22875508
DOI: 10.3760/cma.j.issn.1003-9406.2012.04.019

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MTHFR

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