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Article

Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain.

Acta neuropathologica communications - 21 Aug 2013

Dan Ayaho, Takahashi Muneaki, Masuda-Suzukake Masami, Kametani Fuyuki, Nonaka Takashi, Kondo Hiromi, Akiyama Haruhiko, Arai Takao, Mann David M A, Saito Yuko, Hatsuta Hiroyuki, Murayama Shigeo, Hasegawa Masato

Abstract excerpt

BACKGROUND: Intracytoplasmic inclusions composed of filamentous tau proteins are defining characteristics of neurodegenerative tauopathies, but it remains unclear why different tau isoforms accumulate in different diseases and how they induce abnormal filamentous structures and pathologies. Two tau isoform-specific antibodies, RD3 and RD4, are widely used for immunohistochemical and biochemical studies of tau...

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Identifiers

PMID: 24252707
DOI: 10.1186/2051-5960-1-54
PMCID: PMC3893535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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