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Article

Promoter DNA methylation regulates progranulin expression and is altered in FTLD

13 May 2013

Abstract excerpt

BACKGROUND: Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of neurodegenerative diseases associated with personality changes and progressive dementia. Loss-of-function mutations in the growth factor progranulin (GRN) cause autosomal dominant FTLD, but so far the pathomechanism of sporadic FTLD is unclear. RESULTS: We analyzed whether DNA methylation in the GRN core promoter restricts GRN...

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PMID: 24252647
DOI: 10.1186/2051-5960-1-16

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