Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration.

doi:10.1007/s10072-012-1151-5

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Article

Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Jun 2013

Galimberti Daniela, D'Addario Claudio, Dell'osso Bernardo, Fenoglio Chiara, Marcone Alessandra, Cerami Chiara, Cappa Stefano F, Palazzo M Carlotta, Arosio Beatrice, Mari Daniela, Maccarrone Mauro, Bresolin Nereo, Altamura A Carlo, Scarpini Elio

Abstract excerpt

Mutations in progranulin gene (GRN) are the most common cause of autosomal dominant familial frontotemporal lobar degeneration (FTLD). In addition, GRN variability influences the risk to develop the disease in non-carriers (sporadic FTLD). We evaluated progranulin gene (GRN) promoter methylation levels in peripheral blood mononuclear cells isolated from 38 patients with sporadic FTLD compared with 38 controls,...

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PMID: 22797721
DOI: 10.1007/s10072-012-1151-5

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