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Article

Plasma progranulin levels in cortical dementia phenotypes with asymmetric perisylvian atrophy.

European journal of neurology - 1 Sept 2013

Gómez-Tortosa E, Guerrero-López R, Gil-Neciga E, Franco E, del Ser T, Jiménez Escrig A, Pérez-Pérez J, Sainz M J

Abstract excerpt

BACKGROUND AND PURPOSE: Decreased plasma progranulin levels are a very specific marker for the diagnosis of frontotemporal lobar degeneration (FTLD) caused by mutations in the progranulin gene (GRN). A frequent neuroimaging pattern in this type of dementia is asymmetric cortical atrophy. The aim of this study was to screen for GRN-linked FTLD in cases with different cortical dementia phenotypes and asymmetric...

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PMID: 23724906
DOI: 10.1111/ene.12211

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GRN

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