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Article

Molecular characterization of p16-immunopositive but HPV DNA-negative oropharyngeal carcinomas.

International journal of cancer - 15 May 2014

Rietbergen Michelle M, Snijders Peter J F, Beekzada Derakshan, Braakhuis Boudewijn J M, Brink Arjen, Heideman Daniëlle A M, Hesselink Albertus T, Witte Birgit I, Bloemena Elisabeth, Baatenburg-De Jong Robert J, Leemans C René, Brakenhoff Ruud H

Abstract excerpt

Recent studies have reported that p16 protein overexpression qualifies as a surrogate marker identifying an oncogenic human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC). However, there is still a percentage of OPSCCs that are positive for p16 immunohistochemistry (p16 IHC) but lack HPV DNA. The objective of this study was to characterize this group at the molecular level by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24249631
DOI: 10.1002/ijc.28580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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