SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling.

doi:10.1007/s00109-012-0955-3

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Article

SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling.

Journal of molecular medicine (Berlin, Germany) - 1 Mar 2013

Dasgupta Santanu, Jang Jin Sung, Shao Chunbo, Mukhopadhyay Nitai D, Sokhi Upneet K, Das Swadesh K, Brait Mariana, Talbot Conover, Yung Rex C, Begum Shahnaz, Westra William H, Hoque Mohammad Obaidul, Yang Ping, Yi Joanne E, Lam Stephan, Gazdar Adi F, Fisher Paul B, Jen Jin, Sidransky David

Abstract excerpt

The purpose of this study was to identify key genetic pathways involved in non-small cell lung cancer (NSCLC) and understand their role in tumor progression. We performed a genome wide scanning using paired tumors and corresponding 16 mucosal biopsies from four follow-up lung cancer patients on Affymetrix 250K-NSpI array platform. We found that a single gene SH3GL2 located on human chromosome 9p22 was most...

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PMID: 22968441
DOI: 10.1007/s00109-012-0955-3
PMCID: PMC3691869

Genes

EGFR
STAT3

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