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Article

Polygenic risk for Alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Harris Sarah E, Davies Gail, Luciano Michelle, Payton Antony, Fox Helen C, Haggarty Paul, Ollier William, Horan Michael, Porteous David J, Starr John M, Whalley Lawrence J, Pendleton Neil, Deary Ian J

Abstract excerpt

Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non-pathological cognitive aging is accounted for by common...

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Identifiers

PMID: 24246418
DOI: 10.3233/JAD-131058

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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