Article
Influence of Alzheimer's disease genes on cognitive decline: the Guangzhou Biobank Cohort Study.
Neurobiology of aging - 1 Oct 2014
Gui Hongsheng, Jiang Chao Qiang, Cherny Stacey S, Sham Pak Chung, Xu Lin, Liu Bin, Jin Ya Li, Zhu Tong, Zhang Wei Sen, Thomas G Neil, Cheng Kar Keung, Lam Tai Hing
Abstract excerpt
Cognitive decline is a reduction in cognitive ability usually associated with aging, and those with more extreme cognitive decline either have or are at risk of progressing to mild cognitive impairment and dementia including Alzheimer's disease (AD). We hypothesized that genetic variants predisposing to AD should be predictive of cognitive decline in elderly individuals. We selected 1325 subjects with extreme...
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