Article
Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease.
Inflammatory bowel diseases - 1 Oct 2017
Tronstad Rune R, Kummen Martin, Holm Kristian, von Volkmann Hilde L, Anmarkrud Jarl A, Høivik Marte L, Moum Bjørn, Gilja Odd H, Hausken Trygve, Baines John, Karlsen Tom H, Fiskerstrand Torunn, Hov Johannes R
Abstract excerpt
BACKGROUND: With 25% prevalence of Crohn's disease, Familial GUCY2C diarrhea syndrome (FGDS) is a monogenic disorder potentially suited to study initiating factors in inflammatory bowel disease (IBD). We aimed to characterize the impact of an activating GUCY2C mutation on the gut microbiota in patients with FGDS controlling for Crohn's disease status and to determine whether changes share features with those...
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