Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.

doi:10.1200/JCO.2013.50.8556

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Article

Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jan 2014

Kim Youngwook, Hammerman Peter S, Kim Jaegil, Yoon Ji-ae, Lee Yoomi, Sun Jong-Mu, Wilkerson Matthew D, Pedamallu Chandra Sekhar, Cibulskis Kristian, Yoo Yeong Kyung, Lawrence Michael S, Stojanov Petar, Carter Scott L, McKenna Aaron, Stewart Chip, Sivachenko Andrey Y, Oh In-Jae, Kim Hong Kwan, Choi Yong Soo, Kim Kwhanmien, Shim Young Mog, Kim Kyu-Sik, Song Sang-Yun, Na Kook-Joo, Choi Yoon-La, Hayes D Neil, Kim Jhingook, Cho Sukki, Kim Young-Chul, Ahn Jin Seok, Ahn Myung-Ju, Getz Gad, Meyerson Matthew, Park Keunchil

Abstract excerpt

PURPOSE: Lung squamous cell carcinoma (SCC) is the second most prevalent type of lung cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely because of a lack of systematic understanding of the molecular pathogenesis of the disease. To identify therapeutic...

Topics

Adult
Aged
Aged, 80 and over
Asian People
Carcinoma, Squamous Cell
Class I Phosphatidylinositol 3-Kinases
DNA-Binding Proteins
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Humans

Intracellular Signaling Peptides and Proteins

Kelch-Like ECH-Associated Protein 1

Lung Neoplasms

Male

Middle Aged

Models, Genetic

Mutation

NF-E2-Related Factor 2

Source

Open in PubMed Open full text

Identifiers

PMID: 24323028
DOI: 10.1200/JCO.2013.50.8556
PMCID: PMC4062710

Genes

FGFR3
KEAP1
PTEN
TACC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-24323028-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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