Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.

doi:10.1200/JCO.2013.50.8556

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Article

Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jan 2014

Kim Youngwook, Hammerman Peter S, Kim Jaegil, Yoon Ji-ae, Lee Yoomi, Sun Jong-Mu, Wilkerson Matthew D, Pedamallu Chandra Sekhar, Cibulskis Kristian, Yoo Yeong Kyung, Lawrence Michael S, Stojanov Petar, Carter Scott L, McKenna Aaron, Stewart Chip, Sivachenko Andrey Y, Oh In-Jae, Kim Hong Kwan, Choi Yong Soo, Kim Kwhanmien, Shim Young Mog, Kim Kyu-Sik, Song Sang-Yun, Na Kook-Joo, Choi Yoon-La, Hayes D Neil, Kim Jhingook, Cho Sukki, Kim Young-Chul, Ahn Jin Seok, Ahn Myung-Ju, Getz Gad, Meyerson Matthew, Park Keunchil

Abstract excerpt

PURPOSE: Lung squamous cell carcinoma (SCC) is the second most prevalent type of lung cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely because of a lack of systematic understanding of the molecular pathogenesis of the disease. To identify therapeutic targets and perform comparative analyses of lung SCC, we probed somatic genome alterations of lung SCC by using samples...

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PMID: 24323028
DOI: 10.1200/JCO.2013.50.8556
PMCID: PMC4062710

Genes

FGFR3
KEAP1
PTEN
TACC3

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