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Article

The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness in Candida albicans.

Molecular microbiology - 1 Nov 2012

Sasse Christoph, Dunkel Nico, Schäfer Tina, Schneider Sabrina, Dierolf Franziska, Ohlsen Knut, Morschhäuser Joachim

Abstract excerpt

The pathogenic yeast Candida albicans can develop resistance to the widely used antifungal agent fluconazole, which inhibits ergosterol biosynthesis. Resistance is often caused by gain-of-function mutations in the transcription factors Mrr1, Tac1 and Upc2, which result in constitutive overexpression of multidrug efflux pumps and ergosterol biosynthesis genes respectively. It is not known how the permanently...

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PMID: 22924823
DOI: 10.1111/j.1365-2958.2012.08210.x

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