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Article

Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata.

PloS one - 9 Mar 2011

Ferrari Sélène, Sanguinetti Maurizio, Torelli Riccardo, Posteraro Brunella, Sanglard Dominique

Abstract excerpt

In Candida glabrata, the transcription factor CgPdr1 is involved in resistance to azole antifungals via upregulation of ATP binding cassette (ABC)-transporter genes including at least CgCDR1, CgCDR2 and CgSNQ2. A high diversity of GOF (gain-of-function) mutations in CgPDR1 exists for the upregulation of ABC-transporters. These mutations enhance C. glabrata virulence in animal models, thus indicating that CgPDR1...

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Share to Antifungal Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21408004
DOI: 10.1371/journal.pone.0017589
PMCID: PMC3052359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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