Natural and orthogonal interaction framework for modeling gene-environment interactions with application to lung cancer.

doi:10.1159/000339906

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Article

Natural and orthogonal interaction framework for modeling gene-environment interactions with application to lung cancer.

Human heredity - 1 Jan 2012

Ma Jianzhong, Xiao Feifei, Xiong Momiao, Andrew Angeline S, Brenner Hermann, Duell Eric J, Haugen Aage, Hoggart Clive, Hung Rayjean J, Lazarus Philip, Liu Changlu, Matsuo Keitaro, Mayordomo Jose Ignacio, Schwartz Ann G, Staratschek-Jox Andrea, Wichmann Erich, Yang Ping, Amos Christopher I

Abstract excerpt

OBJECTIVES: We aimed at extending the Natural and Orthogonal Interaction (NOIA) framework, developed for modeling gene-gene interactions in the analysis of quantitative traits, to allow for reduced genetic models, dichotomous traits, and gene-environment interactions. We evaluate the performance of the NOIA statistical models using simulated data and lung cancer data. METHODS: The NOIA statistical models are...

Topics

Case-Control Studies
Computer Simulation
Databases, Factual
Early Detection of Cancer
Gene Frequency
Gene-Environment Interaction
Genetic Loci
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetics, Population

Genome-Wide Association Study

Humans

Logistic Models

Lung Neoplasms

Models, Genetic

Polymorphism, Single Nucleotide

Quantitative Trait, Heritable

Smoking

Source

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Identifiers

PMID: 22889990
DOI: 10.1159/000339906
PMCID: PMC3534768

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