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Article

Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma

12 Jan 2017

Abstract excerpt

Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely reflects the target cell of transformation rather than being required for continued tumor growth. Here, we used a transgenic zebrafish model to show that Myf5 is sufficient to confer...

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PMID: 28080960
DOI: 10.7554/elife.19214

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