Article
Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma.
Cancer cell - 15 Feb 2011
Rubin Brian P, Nishijo Koichi, Chen Hung-I Harry, Yi Xiaolan, Schuetze David P, Pal Ranadip, Prajapati Suresh I, Abraham Jinu, Arenkiel Benjamin R, Chen Qing-Rong, Davis Sean, McCleish Amanda T, Capecchi Mario R, Michalek Joel E, Zarzabal Lee Ann, Khan Javed, Yu Zhongxin, Parham David M, Barr Frederic G, Meltzer Paul S, Chen Yidong, Keller Charles
Abstract excerpt
Embryonal rhabdomyosarcoma (eRMS) shows the most myodifferentiation among sarcomas, yet the precise cell of origin remains undefined. Using Ptch1, p53 and/or Rb1 conditional mouse models and controlling prenatal or postnatal myogenic cell of origin, we demonstrate that eRMS and undifferentiated pleomorphic sarcoma (UPS) lie in a continuum, with satellite cells predisposed to giving rise to UPS. Conversely, p53...
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