Article
Developmental Heterogeneity of Rhabdomyosarcoma.
Cold Spring Harbor perspectives in medicine - 7 Jan 2025
Stevens Bradley T, Hatley Mark E
Abstract excerpt
Rhabdomyosarcoma (RMS) is a pediatric embryonal solid tumor and the most common pediatric soft tissue sarcoma. The histology and transcriptome of RMS resemble skeletal muscle progenitor cells that have failed to terminally differentiate. Thus, RMS is typically thought to arise from corrupted skeletal muscle progenitor cells during development. However, RMS can occur in body regions devoid of skeletal muscle,...
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