HNA-3 gene frequencies in Brazilians and a new polymerase chain reaction-restriction fragment length polymorphism method for HNA-3a/3b genotyping.

doi:10.1111/trf.12493

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Article

HNA-3 gene frequencies in Brazilians and a new polymerase chain reaction-restriction fragment length polymorphism method for HNA-3a/3b genotyping.

Transfusion - 1 Jun 2014

Lopes Larissa Barbosa, Baleotti Wilson, Suzuki Rodrigo Buzinaro, Fabron Antonio, Chiba Akemi Kuroda, Vieira-Filho João Paulo Botelho, de Souza Castro Bianca, Midori Kunioshi Alessandra, Bordin José Orlando

Abstract excerpt

BACKGROUND: HNA-3 antigens are the result of a rs2288904 single-nucleotide polymorphism (SNP) in the CTL2, and the HNA-3a and HNA-3b variants are encoded by a guanine and adenine at Nucleotide Position 461. Anti-HNA-3 are involved in severe transfusion-related acute lung injury reactions and in neonatal alloimmune neutropenia. Since the distribution of the HNA-3 system was unknown in South Americans, in this...

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PMID: 24236643
DOI: 10.1111/trf.12493

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