Article
Gene frequencies of the HNA-4a and -5a neutrophil antigens in Brazilian persons and a new polymerase chain reaction-restriction fragment length polymorphism method for HNA-5a genotyping.
Transfusion - 1 Sept 2006
Cardone José Daniel Braz, Bordin José Orlando, Chiba Akemi Kuroda, Norcia Angela Maria Matico Ikeda, Vieira-Filho João Paulo Botelho
Abstract excerpt
BACKGROUND: The HNA-4a (Mart) and HNA-5a (Ond) antigens are polymorphic variants of alpha(M) (CD11b) and alpha(L) (CD11a) subunits of the beta(2)-integrin, and are associated with single nucleotide polymorphisms (SNP) leading to amino acid dimorphisms. HNA-4a has been linked to alloimmune neonatal neutropenia, but the HNA-5a clinical significance is unclear. STUDY DESIGN AND METHODS: Using a polymerase chain...
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