Determination of human neutrophil antigen-1, -3, -4 and -5 allele frequencies in English Caucasoid blood donors using a multiplex fluorescent DNA-based assay.

doi:10.1111/vox.12016

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Article

Determination of human neutrophil antigen-1, -3, -4 and -5 allele frequencies in English Caucasoid blood donors using a multiplex fluorescent DNA-based assay.

Vox sanguinis - 1 Jul 2013

Cardoso S P, Chong W, Lucas G, Green A, Navarrete C

Abstract excerpt

BACKGROUND AND OBJECTIVES: A number of DNA-based methods to genotype the alleles coding for HNA have been described, but all require the separate amplification and analysis of each allele. The aim was to develop a DNA-based method for simultaneous detection of HNA-1, HNA-3, HNA-4 and HNA-5 alleles. MATERIALS AND METHODS: An allele-specific primer extension method was used in combination with magnetic beads from...

Topics

Alleles
Blood Donors
England
Female
Gene Frequency
Genotype
Humans
Isoantigens
Male
Neutrophils
Sequence Analysis, DNA
White People

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Open in PubMed

Identifiers

PMID: 23398146
DOI: 10.1111/vox.12016

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