Article
Increased cell surface free thiols identify effector CD8+ T cells undergoing T cell receptor stimulation.
PloS one - 1 Jan 2013
Pellom Samuel Troy, Michalek Ryan D, Crump Katie E, Langston P Kent, Juneau Daniel G, Grayson Jason M
Abstract excerpt
Recognition of peptide Major Histocompatibility Complexes (MHC) by the T cell receptor causes rapid production of reactive oxygen intermediates (ROI) in naïve CD8(+) T cells. Because ROI such as H2O2 are membrane permeable, mechanisms must exist to prevent overoxidation of surface proteins. In this study we used fluorescently labeled conjugates of maleimide to measure the level of cell surface free thiols (CSFT)...
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