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Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis

3 Jul 2014

Abstract excerpt

UNLABELLED: Cystathionine β-synthase (CBS) catalyzes metabolic reactions that convert homocysteine to cystathionine. To assess the role of CBS in human glioma, cells were stably transfected with lentiviral vectors encoding shRNA targeting CBS or a nontargeting control shRNA, and subclones were injected into immunodeficient mice. Interestingly, decreased CBS expression did not affect proliferation in vitro but...

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PMID: 24994751
DOI: 10.1158/1541-7786.mcr-14-0184

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