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Article

Low tumor glutathione level as a sensitivity marker for glutamate‑cysteine ligase inhibitors

10 Apr 2018

Abstract excerpt

Previous metabolomic analyses of cancer have revealed elevated glutathione levels in tumors. An inhibitor of cystine uptake was identified to suppress glutathione biosynthesis, leading to ferroptosis, a novel iron-dependent form of cell death that differs from apoptosis and necrosis. Glutamate-cysteine ligase (GCL) is the rate-limiting enzyme in the glutathione biosynthesis pathway. Buthionine sulfoximine (BSO),...

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PMID: 29928324
DOI: 10.3892/ol.2018.8447

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