Article
Neutrophilic superoxide production can assess pharmacological and pharmacogenetic β-adrenoreceptor effects.
Allergy - 1 Aug 2016
Reinartz M T, Wetzke M, Happle C, Kälble S, Scherer R, Kabesch M, Seifert R
Abstract excerpt
Asthma can be controlled well in most patients by inhaled β-adrenoreceptor (β2 AR) agonists and steroids. Poor response to β2 AR agonists is difficult to predict, especially in young children and by lung function testing, which may be affected by multiple influences. As an alternative approach, we analyzed ex vivo neutrophilic superoxide inhibition in response to β2 AR stimulation. In 60 healthy volunteers, this...
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