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Article

α6β1 and α7β1 Integrins Are Required in Schwann Cells to Sort Axons

13 Nov 2013

Abstract excerpt

During development, Schwann cells extend lamellipodia-like processes to segregate large- and small-caliber axons during the process of radial sorting. Radial sorting is a prerequisite for myelination and is arrested in human neuropathies because of laminin deficiency. Experiments in mice using targeted mutagenesis have confirmed that laminins 211, 411, and receptors containing the β1 integrin subunit are required...

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PMID: 24227711
DOI: 10.1523/jneurosci.3179-13.2013

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